How will immunotherapy combination regimens impact the NSCLC treatment landscape?
The pace of change in NSCLC shows no sign of abating. Developments in immunotherapy continue to take centre stage, particularly in first-line treatment. Merck & Co. have a head start in this setting with recent approvals for Keytruda; however, BMS, AstraZeneca, Roche and Merck Group/Pfizer still have much to play for. As fist-line treatment options expand, how will patients be selected for specific therapies, what role will combinations play, and how will these impact second-line treatment decisions? Targeted therapies also continue to generate much interest. KOLs weigh in on how data from the ALEX trial of Alecensa, and new product approvals, could shake up the treatment algorithm for ALK-positive NSCLC, as well as developments in EGFR-, BRAF- and ROS1-positive disease. In this report seven US and five EU KOLs offer candid insights on 12 marketed therapies and seven pipeline drugs.
“I think you are going to see the biggest change in first-line metastatic NSCLC. In the last few months it has changed many times and it will continue to change because first line is where it is easiest to show a difference. Combination IOs will take over; IOs with chemotherapy will be there.”
EU Key Opinion Leader
“Patients will be getting NGS testing the vast majority of the time. We will get far more sophisticated about predicting which patients will benefit the most and least with immunotherapy and we’ll see how we are using immunotherapy now as the dark ages compared to [in five years’ time], like 1975 with chemotherapy.”
US Key Opinion Leader
Marketed Therapies
Pipeline Therapies
KOLs from North America
KOLs from Europe
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