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Targeted Therapies in Asthma: Update Bulletin #1 [April 2018]

Product Code:
Publication Date:
April 2018

Gain new key opinion leader (KOL) insights on the latest events happening in targeted therapies for asthma. Topics covered include; expert opinions on the potential of GSK’s anti-IL-33 mAb GSK3772847; KOL views on dupilumab (Dupixent; Sanofi/Regeneron); and views on the results of the Phase IV OSMO trial carried out in subjects with severe eosinophilic asthma not optimally controlled with Xolair (omalizumab; Novartis/Roche) treatment who were switched from omalizumab to Nucala (mepolizumab; GSK)

Business Questions:

• How do KOLs perceive GSK3772847’s mechanism of action?
• What are KOLs’ views on the design of GSK3772847’s Phase II study?
• What concerns do KOLs raise about using anti-IL-33 therapies in combination?
• Do KOLs anticipate dupilumab use will be limited to those patients with higher eosinophils?
• What advantages and disadvantages does dupilumab have over other biological therapies?
• What safety concerns do KOLs raise regarding the use of dupilumab?
• What impact do experts anticipate the results of the OSMO trial will have on prescribing?
• What are KOLs opinions on the design of the OSMO study?
• How do KOLs anticipate developers of other anti-IL-5s will interpret the results of the OSMO study?


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