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Rheumatoid Arthritis: Update Bulletin #3 [December 2018]

Product Code:
Publication Date:
December 2018

This edition presents key opinion leader (KOL) views on recent developments in the rheumatoid arthritis (RA) market. Topics covered include: Gilead Sciences and Galapagos announcing that the investigational JAK1 inhibitor filgotinib, achieved the primary endpoint of the Phase III FINCH 2 study involving adults with moderately-to-severely active RA who had an inadequate response or intolerance to prior biologic agents; GlaxoSmithKline announcing results from a Phase II dose-ranging study of GSK3196165, an investigational anti-granulocyte macrophage colony-stimulating factor monoclonal (anti GM-CSF) antibody; as well as Eli Lilly and Incyte announcing findings from an updated integrated safety analysis of Olumiant (baricitinib) based on an ongoing long-term extension (LTE) study of RA patients treated up to six years.

Business Questions:

• What are KOLs’ reactions to the filgotinib FINCH 2 results?
• What do experts consider critical in determining filgotinib’s success?
• How do KOLs view GSK 3196165’s mechanism of action?
• What concerns do KOLs have regarding GSK 3196165?
• According to KOLs, how important is the updated integrated safety analysis of Olumiant (baricitinib)?
• According to experts, how is Olumiant currently faring in the US and EU?


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