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Glioblastoma: Update Bulletin #1 [May 2018]

Product Code:
Publication Date:
May 2018

This edition presents key opinion leader (KOL) views on recent developments in the Glioblastoma multiforme (GBM) market. Topics covered include: DelMar Pharmaceuticals’ Phase II development for dianhydrogalactitol (VAL-083), in the MGMT-unmethylated GBM patients; PharmAbcine’s announcing that the US FDA had granted Orphan Drug Designation (ODD) to tanibirumab, an anti-VEGFR2 mAb in Phase II trials for treatment of GBM; and Kazia Therapeutics announcing that the US FDA had granted ODD to GDC-0084, an inhibitor of the PI3K/AKT/mTOR pathway, in Phase II trials for GBM.

Business Questions:

• How do KOLs see the development of DelMar’s novel alkylating agent, VAL-083 for GBM?
• What do KOLs expect from VAL-083 Phase II study in the bevacizumab-refractory GBM patients?
• What prospects does VAL-083 have in bevacizumab-naïve MGMT unmethylated patients?
• How do KOLs rate PharmAbcine’s tanibirumab in GBM?
• Will the anti-VEGFR2 mAb shine in bevacizumab-refractory setting? What do KOLs say?
• How do KOLs see tanibirumab plus pembrolizumab (Keytruda) combination in GBM?
• How do KOLs view the PI3K/AKT/mTOR pathway as a target for GBM?
• What safety concerns do experts have with GDC-0084 specifically, and PI3K/AKT/mTOR pathway, generally?
• Are combinations the best way forward with Kazia’s GDC-0084 or can monotherapy reach the market?
• According to KOLs what does GDC-0084 need to achieve to gain approval?



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